A polyphenol-rich Calafate (Berberis microphylla) extract rescues glucose tolerance in mice fed with cafeteria diet

J. Soto-Covasich, M. Reyes-Farias, R. F. Torres, K. Vasquez, L. Duarte, J. Quezada, P. Jimenez, M. T. Pino, L. Garcia-Nannig, LUIS ALBERTO MERCADO VIANCO, D. F. Garcia-Diaz

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The establishment of a chronic inflammatory state in the adipose tissue contributes to obesity-associated insulin resistance. Hence, disrupting the inflammatory response elicited by obesity remains a relevant target to tackle the modern-world pandemic. We evaluated the anti-inflammatory and insulin-sensitizing effect of Calafate (Berberis microphylla) by producing and characterizing a polyphenol-pure Calafate extract (PPCE). C57BL/6 mice fed with cafeteria diet for 14 weeks were administered PPCE (50 mg/Kg/day) for 4 weeks. PPCE administration rescued glucose tolerance and insulin-elicited AKT phosphorylation in white adipose tissue of diet-induced insulin-resistant mice. Furthermore, the cafeteria diet-induced expression of TNF-alpha and F4/80 was attenuated by PPCE administration, suggesting that PPCE rescues insulin sensibility by ameliorating the obesity-associated inflammatory state. Altogether, our data shows that Calafate represents a natural source of polyphenols with glucose tolerance-improving properties in vivo, suggesting a potential use of PPCE as a complementary tool against insulin resistance.

Original languageEnglish
Article number103856
JournalJournal of Functional Foods
Volume67
DOIs
StatePublished - Apr 2020
Externally publishedYes

Keywords

  • Adipose tissue
  • Glucose tolerance
  • Inflammation
  • Natural product
  • Obesity

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