TY - JOUR
T1 - Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
AU - Mosso G, Lorena
AU - Carvajal M, Cristian
AU - Campino J, Carmen
AU - Rojas O, Auristela
AU - González P, Alexis
AU - Barraza M, Adolfo
AU - Montero L, Joaquín
AU - Fardella B, Carlos
PY - 2002/11
Y1 - 2002/11
N2 - Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11βHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 μg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 μg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11βHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).
AB - Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11βHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 μg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 μg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11βHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).
KW - 11β-Hydroxysteroid dehydrogenases
KW - Aldosterone
KW - Hypertension
KW - Renin-angiotensin system
UR - http://www.scopus.com/inward/record.url?scp=0036878417&partnerID=8YFLogxK
M3 - Article
C2 - 12587501
AN - SCOPUS:0036878417
VL - 130
SP - 1201
EP - 1208
JO - Revista Medica de Chile
JF - Revista Medica de Chile
SN - 0034-9887
IS - 11
ER -