Antifungal study of the resinous exudate and of meroterpenoids isolated from Psoralea glandulosa (Fabaceae)

Alejandro Madrid, Luis Espinoza, Cesar González, Marco Mellado, Joan Villena, Rocío Santander, Viviana Silva, Iván Montenegro

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Ethnopharmacological relevance: Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus. Aim of the study: To evaluate the in vitro antifungal activity of the resin and the active components from P. glandulosa against clinical yeast isolates. Materials and methods: Active compounds were obtained of the resinous exudate from aerial parts of P. glandulosa. Eight species of yeast were exposed to the resin and two major compounds. Minimum inhibitory concentration (MIC80) was determined according to the standard broth microdilution method. Results: Bakuchiol and 3-hydroxy-bakuchiol demonstrated potent activity with the MIC 80 ranging from 4 to >16 and 0.125 to 16 μg/mL, respectively. The resin had some degree of antifungal activity. Conclusions: The overall results provided important information for the potential application of the 3-hydroxy-bakuchiol from P. glandulosa in the therapy of serious infection and skin diseases caused by clinical yeast.

Original languageEnglish
Pages (from-to)809-811
Number of pages3
JournalJournal of Ethnopharmacology
Volume144
Issue number3
DOIs
StatePublished - 18 Dec 2012
Externally publishedYes

Keywords

  • Antifungal activity
  • Meroterpenoids
  • Psoralea glandulosa
  • Resinous exudate

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