Applications of Liquid/Liquid Biphasic Oxidations by Hydrogen Peroxide with Ionic Liquids or Deep Eutectic Solvents

This Minireview focuses on recent applications of ionic liquids (ILs) and deep eutectic solvents (DESs) in biphasic oxidations in which the oxidizing agent corresponds to hydrogen peroxide. Biphasic reactions are accomplished when the substrate presents low or moderate solubility in aqueous (polar) systems and/or when separation of products and byproduct is an issue. The properties of the IL and DES allows the reaction activity to be intensified. On the other hand, the high chemical stability of the ionic solvents allows the use of hydrogen peroxide to minimize solvent degradation and unwanted byproducts. The experimental evidence presented herein shows that ILs and DESs can be used as cocatalysts, catalysts, and solvents to achieve enhanced yields and conversions. The process advantages, in terms of a reduction of volatile solvents, improve the safety and use of the oxidizing agent, which implies the possibility of developing new process improvements in the future.