Bacteriophage production models: An overview

Rodrigo García, Simone Latz, Jaime Romero, Gastón Higuera, Katherine García, Roberto Bastías

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


The use of bacteriophages has been proposed as an alternative method to control pathogenic bacteria. During recent years several reports have been published about the successful use of bacteriophages in different fields such as food safety, agriculture, aquaculture, and even human health. Several companies are now commercializing bacteriophages or bacteriophage-based products for therapeutic purposes. However, this technology is still in development and there are challenges to overcome before bacteriophages can be widely used to control pathogenic bacteria. One big hurdle is the development of efficient methods for bacteriophage production. To date, several models for bacteriophage production have been reported, some of them evaluated experimentally. This mini-review offers an overview of different models and methods for bacteriophage production, contrasting their principal differences.

Original languageEnglish
Article number1187
JournalFrontiers in Microbiology
Issue numberJUN
StatePublished - 2019


  • Bacteriophage
  • Bacteriophage production
  • Bacteriophage therapy
  • Phage production models
  • Phage therapy


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