Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

Marcos Lorca, David Cabezas, Ileana Araque, Andrés Terán, Santiago Hernández, Marco Mellado, Luis Espinoza, Jaime Mella

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure–activity relationship based on the available information.

Original languageEnglish
Article number109153
StatePublished - Feb 2023
Externally publishedYes


  • Antitumor
  • Brassinolide
  • Brassinosteroid
  • Cancer
  • Epibrassinolide
  • SAR


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