Communication between gastrointestinal bacteria and the nervous system

Javier A. Bravo, Marcela Julio-Pieper, Paul Forsythe, Wolfgang Kunze, Timothy G. Dinan, John Bienenstock, John F. Cryan

Research output: Contribution to journalReview articlepeer-review

182 Scopus citations


In the past few years, intestinal microbiota has emerged as a novel target for the treatment of gut-brain axis alterations. These include functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions. Thus, modulation of the microbiota (e.g. with the use of probiotics) could be proposed as a novel strategy not only for the treatment of IBS but also as an adjuvant for psychiatric treatment of anxiety and depression.

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalCurrent Opinion in Pharmacology
Issue number6
StatePublished - Dec 2012


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