Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides

MARIA VERONICA ROJAS DURAN, Luis Rivas, Constanza Cárdenas, Fanny Guzmán

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Cyanobacteria and microalgae are oxygen-producing photosynthetic unicellular organisms encompassing a great diversity of species, which are able to grow under all types of extreme environments and exposed to a wide variety of predators and microbial pathogens. The antibacterial compounds described for these organisms include alkaloids, fatty acids, indoles, macrolides, peptides, phenols, pigments and terpenes, among others. This review presents an overview of antibacterial peptides isolated from cyanobacteria and microalgae, as well as their synergism and mechanisms of action described so far. Antibacterial cyanopeptides belong to different orders, but mainly from Oscillatoriales and Nostocales. Cyanopeptides have different structures but are mainly cyclic peptides. This vast peptide repertoire includes ribosomal and abundant non-ribosomal peptides, evaluated by standard conventional methodologies against pathogenic Gram-negative and Gram-positive bacteria. The antibacterial activity described for microalgal peptides is considerably scarcer, and limited to protein hydrolysates from two Chlorella species, and few peptides from Tetraselmis suecica. Despite the promising applications of antibacterial peptides and the importance of searching for new natural sources of antibiotics, limitations still persist for their pharmaceutical applications.

Original languageEnglish
Issue number24
StatePublished - 9 Dec 2020
Externally publishedYes


  • antibacterial activity
  • antimicrobial
  • bioactive compounds
  • cyanobacteria
  • microalgae
  • peptide


Dive into the research topics of 'Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides'. Together they form a unique fingerprint.

Cite this