Deprotection reagents in Fmoc solid phase peptide synthesis: Moving away from piperidine?

Physics & Astronomy

• piperidine 81%
• reagents 55%
• peptides 54%
• solid phases 45%
• synthesis 35%
• toxicity 20%
• synthesizers 11%
• products 10%
• amides 10%
• hydrophobicity 9%
• amines 9%
• reaction products 9%
• availability 8%
• resins 8%
• polarity 7%
• purity 7%
• microwaves 5%

Medicine & Life Sciences

• 9-fluorenylmethoxycarbonyl 100%
• Solid-Phase Synthesis Techniques 79%
• piperidine 70%
• Rink amide resin 19%
• 4-methylpiperidine 18%
• Peptides 15%
• Piperazine 11%
• Microwaves 9%
• Hydrophobic and Hydrophilic Interactions 9%
• Amines 8%

Chemistry

• Piperidine 50%
• Peptide 28%
• Piperazine 26%
• Secondary Amine 24%
• Hydrophobicity 21%
• Polarity 20%
• Blue 17%
• Amide 17%
• Purity 12%
• Reaction Yield 9%
• Time 8%