@article{9bfce972191f40f8a3746f30760fe478,
title = "Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling",
abstract = "Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 μm is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology. Seeding mesenchymal stem cells (MSCs) onto both cross-linked and non-cross-linked PGl fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load cross-linked PGl with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering.",
author = "{De Oliveira}, {Fernando C.S.} and Dinorath Olvera and Sawkins, {Michael J.} and Cryan, {Sally Ann} and Kimmins, {Scott D.} and {Da Silva}, {Tatiane Eufrasio} and Kelly, {Daniel J.} and Duffy, {Garry P.} and Cathal Kearney and Andreas Heise",
note = "Funding Information: F.C.S.d.O. acknowledges funding from the Brazilian Government-CAPES Grand Number No. 13695/2013-04. S.D.K. acknowledges support from European Union{\textquoteright}s Horizon 2020 Framework Program for Research, Technological Development and Demonstration (Marie Curie Intra-European Fellowship for Career Development, 656259). The authors acknowledge support from Spraybase and the Science Foundation Ireland Research Centre CURAM (Grant Number 13/RC/2073). This work was supported by the Irish Research Council (IRC) [IRCSET P/G S/Ship.13]. C.J.K. acknowledges funding from European Union for a Marie Curie European Reintegration Grant under H2020 (Project Reference 659715), RCSI{\textquoteright}s Office of Research and Innovation Seed Fund Award (Grant Number GR 14-0963) and Science Foundation Ireland (AMBER, SFI/ 12/RC/2278). G.P.D and T.E.d.S. acknowledge funding from Science Foundation Ireland (AMBER, SFI/12/RC/2278). The authors would like to thank Dr. Brendan Twamley from Trinity College Dublin for the XRD analysis and Dr. Larisa Florea from Dublin City University for the Raman spectroscopy analysis. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = dec,
day = "11",
doi = "10.1021/acs.biomac.7b01335",
language = "English",
volume = "18",
pages = "4292--4298",
journal = "Biomacromolecules",
issn = "1525-7797",
number = "12",
}