Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour

Dervla O'Malley, MARCELA JULIO PIEPER, Sinead M. Gibney, Timothy G. Dinan, John F. Cryan

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Stress and anxiety are important causal and exacerbating factors in functional gastro-intestinal (GI) disorders such as irritable bowel syndrome. Stress affects GI motility, faecal transit and visceral pain sensitivity. Additionally, permeability and function of the gut epithelium, which acts as a barrier between the external environment and the body's internal milieu is altered by stress. However, the effects of an enhanced stress response on colonic morphology require further investigation. We have used two animal models of stress and anxiety, the maternally separated (MS) and Wistar Kyoto (WKY) rats to examine colonic morphology. These rats exhibit increased anxiety behaviours, visceral hypersensitivity and increased stress-induced defecation in the open field arena. At a morphological level, increased mucus secretion and an associated elevation in the number of mucosal goblet cells was observed in the high anxiety rats. Additionally, the mucosal layer was flattened in MS and WKY rats, a finding indicative of mild mucosal damage. Furthermore, the muscular layer of the distal colon in these animals was thickened, an observation that may have implications for faecal transit and visceral pain perception. This study provides evidence of altered colonic function and morphology in two animal models with a heightened response to stress.

Original languageEnglish
Pages (from-to)114-122
Number of pages9
JournalStress
Volume13
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Colonic morphology
  • Irritable bowel syndrome
  • Maternal separation
  • Open field
  • Stress
  • Wistar Kyoto

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