TY - JOUR
T1 - Distribution, metabolism, and toxicity of antimony species in wistar rats. A bio-analytical approach
AU - Ogra, Yasumitsu
AU - Roldán, Nicole
AU - Verdugo, Marcelo
AU - Gonzalez, Alexis A.
AU - Suzuki, Noriyuki
AU - Quiroz, Waldo
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/6
Y1 - 2023/6
N2 - This work studied the distribution, reactivity, and biological effects of pentavalent or trivalent antimony (Sb(V), Sb(III)) and N-methylglucamine antimonate (NMG-Sb(V)) in Wistar Rats. The expression of fibrosis genes such as α − SMA, PAI-1, and CTGF were determined in Liver, and Kidney tissues. Wistar rats were treated with different concentrations of Sb(V), Sb(III), As(V) and As(III), and MA via intra-peritoneal injections. The results indicated a noteworthy elevation in mRNA levels of plasminogen activator 1 (PAI-1) in the kidneys of rats that were injected. The main accumulation site for Sb(V) was observed to be the liver, from which it is primarily excreted in its reduced form (Sb(III)) through the urine. The generation of Sb(III) in the kidneys has been found to induce damage through the expression of α-SMA and CTGF, and also lead to a higher creatinine clearance compared to As(III).
AB - This work studied the distribution, reactivity, and biological effects of pentavalent or trivalent antimony (Sb(V), Sb(III)) and N-methylglucamine antimonate (NMG-Sb(V)) in Wistar Rats. The expression of fibrosis genes such as α − SMA, PAI-1, and CTGF were determined in Liver, and Kidney tissues. Wistar rats were treated with different concentrations of Sb(V), Sb(III), As(V) and As(III), and MA via intra-peritoneal injections. The results indicated a noteworthy elevation in mRNA levels of plasminogen activator 1 (PAI-1) in the kidneys of rats that were injected. The main accumulation site for Sb(V) was observed to be the liver, from which it is primarily excreted in its reduced form (Sb(III)) through the urine. The generation of Sb(III) in the kidneys has been found to induce damage through the expression of α-SMA and CTGF, and also lead to a higher creatinine clearance compared to As(III).
KW - CTGF
KW - Kidney
KW - PAI-1
KW - Sb(III) distribution
KW - Sb(III) reduction
KW - Urine
KW - α- SMA
UR - http://www.scopus.com/inward/record.url?scp=85163320815&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2023.104160
DO - 10.1016/j.etap.2023.104160
M3 - Article
C2 - 37236494
AN - SCOPUS:85163320815
SN - 1382-6689
VL - 100
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
M1 - 104160
ER -