DNA methylation in Trypanosoma cruzi

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Abstract

DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. Probably T. cruzi DNA also contains N6-methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalFEBS Letters
Volume263
Issue number1
DOIs
StatePublished - 9 Apr 1990

Keywords

  • 5-Methylcytosine
  • Base composition
  • DNA methylation
  • Trypanosoma cruzi

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