Efectos del ejercicio físico sobre la cognición en mujeres mayores tratadas con lovastatina

Translated title of the contribution: Effects of exercise on the cognition of older women treated with lovastatin

Edgardo Molina-Sotomayor, Rocío Arreguín-Moreno, Fernando Rodríguez-Rodríguez, Francisco Pradas, Juan Antonio León, José Antonio González-Jurado

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


INTRODUCTION: The deterioration of cognition is highly predominant in older adults. OBJECTIVE: The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with lovastatin. MATERIALS AND METHODS: Participants were distributed in two groups: An exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test, and the cardiorespiratory fitness was measured using the six-minute walking test (6MWT). RESULTS: EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and in and calculation. The decrease in LDL-C was not significant (p>0.05). CONCLUSION: A controlled and progressive walking program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.

Translated title of the contributionEffects of exercise on the cognition of older women treated with lovastatin
Original languageSpanish
Pages (from-to)496-506
Number of pages11
JournalBiomedica : revista del Instituto Nacional de Salud
Issue number4
StatePublished - 1 Dec 2018


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