Abstract
Introduction: The deterioration of cognition is highly predominant in older adults. Objective: The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with lovastatin. Materials and methods: Participants were distributed in two groups: An exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test, and the cardiorespiratory fitness was measured using the six-minute walking test (6MWT). Results: EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and in and calculation. The decrease in LDL-C was not significant (p>0.05). Conclusion: A controlled and progressive walking program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.
| Translated title of the contribution | Effects of exercise on the cognition of older women treated with lovastatin |
|---|---|
| Original language | English |
| Pages (from-to) | 496-506 |
| Number of pages | 11 |
| Journal | Biomedica : revista del Instituto Nacional de Salud |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2018 |
Keywords
- Exercise
- aging
- cognición
- cognition
- dislipidemias
- dyslipidemia
- ejercicio
- envejecimiento
- hydroxymethylglutaryl-CoA reductase inhibitors
- inhibidores de hidroximetilglutaril-CoA reductasa
- mental health
- salud mental
