Effects of oral propranolol for circumscribed choroidal hemangioma

Karlos Frederico Castelo Branco Sancho, CLAUDIO MAURICIO ZETT LOBOS, Iran Gonçalves Júnior, Melina Correia Morales, Maurício Maia, Rubens Belfort Mattos Neto

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: We aimed to evaluate the effects of oral propranolol for circumscribed choroidal hemangioma. Methods: In this prospective, longitudinal interventional study, we administered oral propranolol at a dosage of 1.5 mg/kg/day to five patients with circumscribed choroidal hemangioma. We then evaluated visual acuity, binocular indirect ophthalmoscopy, optical coherence tomography, optical coherence tomography angiography, fluorescein and indocyanine green angiography, and ocular ultrasonography at regular intervals and compared changes from the baseline assessments. Results: No clinical or diagnostic changes were observed in the sizes of the circumscribed choroidal hemangiomas during treatment. Complications due to the hemangioma were reduced in the first four months of treatment, followed by maintenance, before worsening in the subsequent three months. Conclusions: The study showed that oral propranolol at a dose of 1.5 mg/kg/day did not offer effective monotherapy in the treatment of circumscribed choroidal hemangioma.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalArquivos Brasileiros de Oftalmologia
Volume81
Issue number3
DOIs
StatePublished - 1 May 2018
Externally publishedYes

Keywords

  • Choroid neoplasms
  • Hemangioma
  • Indocyanine green
  • Optical coherence
  • Propranolol
  • Tomography

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