Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model

Alexis A. Gonzalez, Emily L. Olsen, Stephanie Z. Killeen, Robert V. Blair, Surya V. Seshan, Edgar A. Jaimes, Chad J. Roy, Minolfa C. Prieto

Research output: Contribution to journalArticlepeer-review

Abstract

Increases of soluble urokinase plasminogen activator receptor (suPAR) were measured in both urine and plasma of a Chlorocebus aethiops (African green monkey; AGM) mucosal infected with SARS-CoV-2. The data indicate that elevated suPAR may be associated with renal dysfunction and pathology in the context of COVID-19.

Original languageEnglish
JournalJournal of Medical Primatology
DOIs
StateAccepted/In press - 2022
Externally publishedYes

Keywords

  • acute kidney injury
  • African green monkey
  • nonhuman primate
  • renal injury
  • SARS-CoV-2

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