Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas

PAULINA SCHMITT RIVERA, Julien de Lorgeril, Yannick Gueguen, Delphine Destoumieux-Garzón, Evelyne Bachère

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalDevelopmental and Comparative Immunology
Volume37
Issue number3-4
DOIs
StatePublished - 1 Jul 2012

Keywords

  • Bactericidal/permeability-increasing protein
  • Bivalve mollusk
  • Defensin
  • Innate immunity
  • Pacific oyster
  • Proline-rich peptide
  • Vibrio

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