Facile Approach to Covalent Copolypeptide Hydrogels and Hybrid Organohydrogels

Saltuk B. Hanay, Joanne O'Dwyer, Scott D. Kimmins, Fernando C.S. De Oliveira, Matthew G. Haugh, Fergal J. O'Brien, Sally Ann Cryan, Andreas Heise

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Crosslinking of tryptophan (Trp) containing copolypeptides with varying ratios of benzyl-l-glutamate (BLG) and Nα-(carbobenzyloxy)-l-lysine (Z-Lys) is achieved by the selective reaction with hexamethylene-bis-TAD (bisTAD). Conversion of the resulting organogels into biocompatible hydrogels by full BLG or Z-Lys deprotection is demonstrated. Moreover, diffusion controlled deprotection allows the design of macroscopic hybrid organohydrogels comprising hydrophilic as well as hydrophobic regions at a desired ratio and position. FTIR and SEM analysis confirm the coexistence of both hydrophilic and hydrophobic segments in one copolypeptide piece. Selective loading of hydrogel and organogel segments with hydrophilic and hydrophobic dyes, respectively, is observed on macroscopic amphiphilic gels and films. These materials offer significant potential as dual-loaded drug release gels as well as tissue engineering platforms.

Original languageEnglish
Pages (from-to)944-949
Number of pages6
JournalACS Macro Letters
Issue number8
StatePublished - 21 Aug 2018
Externally publishedYes


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