Free L-phosphotyrosine activates human platelets: molecular evidence for a new signal transducer.

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Abstract

Human platelets, either purified or plasma-enriched, are activated when exposed to free L-phosphotyrosine. Physical aggregation is similar to that induced by collagen, although with distinctive biochemical features. Among these, a mobility shift of a GTP-binding protein specifically recognized by an anti-Ki-v-ras monoclonal antibody and an altered pattern of low molecular weight phosphorylated polypeptides are the most outstanding features. Since free phosphotyrosine is detected in platelets extracts, its role as a new signal transducer as well as its putative modulating action over protein phosphorylation are discussed.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume38
Issue number5-6
StatePublished - 1 Jan 1992

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