In vitro and in vivo biotransformation of glucosinolates from mashua (Tropaeolum tuberosum) by lactic acid bacteria

Ana Aguilar-Galvez, Diego García-Ríos, Daniel Ramírez-Guzmán, Johana Lindo, Rosana Chirinos, Romina Pedreschi, David Campos

Research output: Contribution to journalArticlepeer-review

Abstract

Mashua (Tropaeolum tuberosum) is an Andean tuber with a high content of glucosinolates (GLSs). GLSs subjected to biotransformation by plant enzymes or enzymes of the gastrointestinal microbiota give rise to biologically active compounds, to which chemo preventive properties are attributed. In this work, the biotransformation of mashua GLSs was evaluated in vitro by six strains of lactic acid bacteria (LAB) and in vivo using rats with and without previous LAB dosing. The results showed that L. rhamnosus GG utilized the totality of glucosinalbin and glucotropaeolin, and 46.7 % of glucoaubrietin. Four GLSs derivatives were detected. The GLSs were absorbed and metabolized by the rats with low contents in feces (0.02 %) and urine (0.59 %) and were detected up to 3 h after consumption in plasma. The results showed that probiotic bacteria play an important role in transforming GLSs into beneficial compounds for the health of consumers.

Original languageEnglish
Article number134631
JournalFood Chemistry
Volume404
DOIs
StatePublished - 15 Mar 2023
Externally publishedYes

Keywords

  • Glucosinolate biotransformation
  • Isothiocynates
  • Lactic acid bacteria
  • Nitriles
  • Rats
  • Tropaeolum tuberosum

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