Inhibitory effect of the Ascorbic Acid on photodegradation of pharmaceuticals compounds exposed to UV-B radiation

Consuelo León; Claudio Henríquez; Nicolás López; Georgina Sanchez; Bárbara Pastén; Patricio Baeza; Juan Ojeda

doi:10.1016/j.jpap.2021.100035

Inhibitory effect of the Ascorbic Acid on photodegradation of pharmaceuticals compounds exposed to UV-B radiation

Consuelo León, Claudio Henríquez, Nicolás López, Georgina Sanchez, Bárbara Pastén, Patricio Baeza, Juan Ojeda

INSTITUTE OF CHEMISTRY

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The inhibitory effect of Ascorbic Acid (AA) on some pharmaceuticals compounds most commercialized in Chile when are exposed to the UV-B radiation was studied. The Nonsteroidal Anti-inflammatory Drugs (NSAIDs) paracetamol, ibuprofen, and ketoprofen, the fluoroquinolones ciprofloxacin and moxifloxacin and the statin atorvastatine were tested using plasma concentrations. The pharmaceutical solutions without and with AA were irradiated with irradiation dose of 216μW cm⁻² and its constant and percentage of photodegradation was determined. The results showed that the most of the pharmaceuticals solutions are unstable to UV-B radiation, with the exception of paracetamol, which remained stable after 120 minutes of irradiation. The ketoprofen and ciprofloxacin solutions were the most unstable, reaching a 100 % of photodegradation. The incorporation of AA decreases the percentage and photodegradation constant in all pharmaceuticals solutions. The inhibitory effect on UV-B radiation produced by the AA, can be due to the ability of this vitamin of act as screener or UV light absorbers or react with free radicals and reducing reactive oxygen species, which would cause the structural degradation of drugs.

Original language	English
Article number	100035
Journal	Journal of Photochemistry and Photobiology
Volume	7
DOIs	https://doi.org/10.1016/j.jpap.2021.100035
State	Published - Sep 2021

Keywords

Ascorbic acid
Inhibitory effect
Pharmaceuticals
Photodegradation
Radiation UV-B

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10.1016/j.jpap.2021.100035

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title = "Inhibitory effect of the Ascorbic Acid on photodegradation of pharmaceuticals compounds exposed to UV-B radiation",

abstract = "The inhibitory effect of Ascorbic Acid (AA) on some pharmaceuticals compounds most commercialized in Chile when are exposed to the UV-B radiation was studied. The Nonsteroidal Anti-inflammatory Drugs (NSAIDs) paracetamol, ibuprofen, and ketoprofen, the fluoroquinolones ciprofloxacin and moxifloxacin and the statin atorvastatine were tested using plasma concentrations. The pharmaceutical solutions without and with AA were irradiated with irradiation dose of 216μW cm−2 and its constant and percentage of photodegradation was determined. The results showed that the most of the pharmaceuticals solutions are unstable to UV-B radiation, with the exception of paracetamol, which remained stable after 120 minutes of irradiation. The ketoprofen and ciprofloxacin solutions were the most unstable, reaching a 100 % of photodegradation. The incorporation of AA decreases the percentage and photodegradation constant in all pharmaceuticals solutions. The inhibitory effect on UV-B radiation produced by the AA, can be due to the ability of this vitamin of act as screener or UV light absorbers or react with free radicals and reducing reactive oxygen species, which would cause the structural degradation of drugs.",

keywords = "Ascorbic acid, Inhibitory effect, Pharmaceuticals, Photodegradation, Radiation UV-B",

author = "Consuelo Le{\'o}n and Claudio Henr{\'i}quez and Nicol{\'a}s L{\'o}pez and Georgina Sanchez and B{\'a}rbara Past{\'e}n and Patricio Baeza and Juan Ojeda",

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year = "2021",

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doi = "10.1016/j.jpap.2021.100035",

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T1 - Inhibitory effect of the Ascorbic Acid on photodegradation of pharmaceuticals compounds exposed to UV-B radiation

AU - León, Consuelo

AU - Henríquez, Claudio

AU - López, Nicolás

AU - Sanchez, Georgina

AU - Pastén, Bárbara

AU - Baeza, Patricio

AU - Ojeda, Juan

PY - 2021/9

Y1 - 2021/9

N2 - The inhibitory effect of Ascorbic Acid (AA) on some pharmaceuticals compounds most commercialized in Chile when are exposed to the UV-B radiation was studied. The Nonsteroidal Anti-inflammatory Drugs (NSAIDs) paracetamol, ibuprofen, and ketoprofen, the fluoroquinolones ciprofloxacin and moxifloxacin and the statin atorvastatine were tested using plasma concentrations. The pharmaceutical solutions without and with AA were irradiated with irradiation dose of 216μW cm−2 and its constant and percentage of photodegradation was determined. The results showed that the most of the pharmaceuticals solutions are unstable to UV-B radiation, with the exception of paracetamol, which remained stable after 120 minutes of irradiation. The ketoprofen and ciprofloxacin solutions were the most unstable, reaching a 100 % of photodegradation. The incorporation of AA decreases the percentage and photodegradation constant in all pharmaceuticals solutions. The inhibitory effect on UV-B radiation produced by the AA, can be due to the ability of this vitamin of act as screener or UV light absorbers or react with free radicals and reducing reactive oxygen species, which would cause the structural degradation of drugs.

AB - The inhibitory effect of Ascorbic Acid (AA) on some pharmaceuticals compounds most commercialized in Chile when are exposed to the UV-B radiation was studied. The Nonsteroidal Anti-inflammatory Drugs (NSAIDs) paracetamol, ibuprofen, and ketoprofen, the fluoroquinolones ciprofloxacin and moxifloxacin and the statin atorvastatine were tested using plasma concentrations. The pharmaceutical solutions without and with AA were irradiated with irradiation dose of 216μW cm−2 and its constant and percentage of photodegradation was determined. The results showed that the most of the pharmaceuticals solutions are unstable to UV-B radiation, with the exception of paracetamol, which remained stable after 120 minutes of irradiation. The ketoprofen and ciprofloxacin solutions were the most unstable, reaching a 100 % of photodegradation. The incorporation of AA decreases the percentage and photodegradation constant in all pharmaceuticals solutions. The inhibitory effect on UV-B radiation produced by the AA, can be due to the ability of this vitamin of act as screener or UV light absorbers or react with free radicals and reducing reactive oxygen species, which would cause the structural degradation of drugs.

KW - Ascorbic acid

KW - Inhibitory effect

KW - Pharmaceuticals

KW - Photodegradation

KW - Radiation UV-B

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Inhibitory effect of the Ascorbic Acid on photodegradation of pharmaceuticals compounds exposed to UV-B radiation

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