TY - JOUR
T1 - Innate immune system and preeclampsia
AU - Perez-Sepulveda, Alejandra
AU - Torres, Maria Jose
AU - Khoury, Maroun
AU - Illanes, Sebastian E.
PY - 2014
Y1 - 2014
N2 - Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE
AB - Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE
KW - Immunomodulation
KW - Mesenchymal stem cells
KW - Preeclampsia
KW - Th1-th17
KW - Th2-treg
UR - http://www.scopus.com/inward/record.url?scp=84905484076&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2014.00244
DO - 10.3389/fimmu.2014.00244
M3 - Review article
AN - SCOPUS:84905484076
VL - 5
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - MAY
M1 - 244
ER -