Investigating gut permeability in animal models of disease

Marianela González-González, Camilo Díaz-Zepeda, Johana Eyzaguirre-Velásquez, Camila González-Arancibia, Javier A. Bravo, Marcela Julio-Pieper

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

A growing number of investigations report the association between gut permeability and intestinal or extra-intestinal disorders under the basis that translocation of gut luminal contents could affect tissue function, either directly or indirectly. Still, in many cases it is unknown whether disruption of the gut barrier is a causative agent or a consequence of these conditions. Adequate experimental models are therefore required to further understand the pathophysiology of health disorders associated to gut barrier disruption and to develop and test pharmacological treatments. Here, we review the current animal models that display enhanced intestinal permeability, and discuss (1) their suitability to address mechanistic questions, such as the association between gut barrier alterations and disease and (2) their validity to test potential treatments for pathologies that are characterized by enhanced intestinal permeability.

Original languageEnglish
Article number1962
JournalFrontiers in Physiology
Volume10
Issue numberJAN
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Barrier
  • Epithelium
  • Gastrointestinal disorders
  • Gut
  • Permeability

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