Local Search for the Direct Aperture Optimisation in IMRT

Mauricio Moyano, Guillermo Cabrera-Guerrero

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Radiotherapy (also called Radiation therapy) is a cancer treatment that uses high doses of radiation to destroy cancer cells and shrink tumors. Into external radiotherapy, there is the Intensity Modulated Radiation Therapy (known as IMRT), where it is taken a specific part of the body through the deliver the dose from different angles to damage the tumor, avoiding surrounding organs.When IMRT is approached as a sequential problem, we first need to establish a set of beam angles from which radiation will be released then, the radiation intensities for each selected beam angles are computed. Finally, the sequence of apertures we need to deliver the computed treatment plan is generated. Unlike this sequential approach, in the Direct Aperture Optimization (DAO) problems, constraints associated with the number of deliverable aperture shapes, just as some physical constraints, are taken into consideration while the intensities optimisation process is taking place. According to some authors, DAO generates better treatments with fewer apertures for IMRT.In this work, we propose a heuristic algorithm, mixing a local search algorithm and mathematical programming to solve the DAO problem. We apply our algorithm on a prostate cancer case and compare ours results with those obtained in the sequential approach. Results show that our algorithms can find treatment plans in competitive time when considering the number of deliverable aperture shapes.

Original languageEnglish
Title of host publication2020 39th International Conference of the Chilean Computer Science Society, SCCC 2020
PublisherIEEE Computer Society
ISBN (Electronic)9781728183282
DOIs
StatePublished - 16 Nov 2020
Externally publishedYes
Event39th International Conference of the Chilean Computer Science Society, SCCC 2020 - Coquimbo, Chile
Duration: 16 Nov 202020 Nov 2020

Publication series

NameProceedings - International Conference of the Chilean Computer Science Society, SCCC
Volume2020-November
ISSN (Print)1522-4902

Conference

Conference39th International Conference of the Chilean Computer Science Society, SCCC 2020
Country/TerritoryChile
CityCoquimbo
Period16/11/2020/11/20

Keywords

  • direct aperture optimisation
  • intensity modulated radiation therapy
  • local search

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