Mapping and quantifying neuropeptides in the enteric nervous system

Alex González-Vergara, Benjamín Benavides, Marcela Julio-Pieper

Research output: Contribution to journalReview articlepeer-review


Neuropeptides are a highly diverse group of signaling molecules found in the central nervous system (CNS) and peripheral organs, including the enteric nervous system (ENS). Increasing efforts have been focused on dissecting the role of neuropeptides in both neural- and non-neural-related diseases, as well as their potential therapeutic value. In parallel, accurate knowledge on their source of production and pleiotropic functions is still needed to fully understand their implications in biological processes. This review will focus on the analytical challenges involved in studying neuropeptides, particularly in the ENS, a tissue where their abundance is low, together with opportunities for further technical development.

Original languageEnglish
Article number109882
JournalJournal of Neuroscience Methods
StatePublished - 1 Jun 2023


  • Enteric nervous system
  • Myenteric plexus
  • Neuropeptides
  • Submucosal plexus


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