MHC mediated resistance to Piscirickettsia salmonis in salmonids farmed in Chile

Daniela Gómez, Pablo Conejeros, Sofia Consuegra, SERGIO HERNAN MARSHALL GONZALEZ

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Piscirickettsia salmonis is the most persistent and threatening pathogen for Chilean aquaculture. In our search for alternatives to control the disease, we analyzed class II polymorphic genes of the Major Histocompatibility Complex (MHC) in juvenile fish trying to find alleles that may confer resistance or susceptibility to the agent in the three major salmonid species cultured in Chile: Salmo salar, Oncorhynchus mykiss and Oncorhynchus kisutch. DNA from farmed fish naturally exposed to the pathogen in different aquaculture centers in Chile were analyzed via PCR for the MHC class II alpha and beta loci (DAA and DAB), and characterized by denaturant gradient gel electrophoresis (DGGE) followed by DNA sequencing. The comparison between alleles present in either healthy or diseased individuals clearly demonstrated allelic differences between the two populations, specifically for the DAB locus in the three species and only for the DAA locus in S. salar. We conclude that a thorough analysis of the allelic differences identified between fish naturally susceptible/resistant to P. salmonis could potentiate MHC to become a powerful genetic marker for both prophylactic and breeding purposes.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
Issue number1-2
StatePublished - 27 Jul 2011


  • Class II
  • MHC
  • Oncorhynchus kisutch
  • Oncorhynchus mykiss
  • Piscirickettsia salmonis
  • Salmo salar

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