TY - JOUR
T1 - Microalgae extracts
T2 - Potential anti-Trypanosoma cruzi agents?
AU - Veas, Rhonda
AU - Rojas-Pirela, Maura
AU - Castillo, Christian
AU - Olea-Azar, Claudio
AU - Moncada, Mauricio
AU - Ulloa, Pablo
AU - Rojas, Verónica
AU - Kemmerling, Ulrike
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/7
Y1 - 2020/7
N2 - Introduction: Chagas disease, caused by the protozoan parasiteTrypanosoma cruzi, has no effective treatment available. On the other hand, microalgae are aquatic organisms that constitute an interesting reservoir of biologically active metabolites. Moreover, some species of green and red algae present anti-protozoan activity. Our aim was to study the antiparasitic effects of aqueous, methanolic and ethanolic extracts from different microalgae. Methods and Results: : Our results show that the methanolic extracts of S. obliquus and T. suecica as well as the ethanolic extracts of C. reinhardtii and T. suecica present trypanocidal activity on the infective extracellular trypomastigotes and intracellular amastigotes. In addition, the ethanolic extract of C. reinhardtii potentiates the activity of the conventional antichagasic drug nifurtimox. In order to identify some potential compounds with trypanocidal activity, we performed a phytochemical screening analyzing the presence of phenolic compounds, pigments and terpenoids. Conclusion: The different microalgae extracts, particularly the ethanolic extract ofC. reinhardtii, are promising potential candidates for the development of future natural antichagasic drugs.
AB - Introduction: Chagas disease, caused by the protozoan parasiteTrypanosoma cruzi, has no effective treatment available. On the other hand, microalgae are aquatic organisms that constitute an interesting reservoir of biologically active metabolites. Moreover, some species of green and red algae present anti-protozoan activity. Our aim was to study the antiparasitic effects of aqueous, methanolic and ethanolic extracts from different microalgae. Methods and Results: : Our results show that the methanolic extracts of S. obliquus and T. suecica as well as the ethanolic extracts of C. reinhardtii and T. suecica present trypanocidal activity on the infective extracellular trypomastigotes and intracellular amastigotes. In addition, the ethanolic extract of C. reinhardtii potentiates the activity of the conventional antichagasic drug nifurtimox. In order to identify some potential compounds with trypanocidal activity, we performed a phytochemical screening analyzing the presence of phenolic compounds, pigments and terpenoids. Conclusion: The different microalgae extracts, particularly the ethanolic extract ofC. reinhardtii, are promising potential candidates for the development of future natural antichagasic drugs.
KW - Anti-Protozoan activity
KW - Microalgae extracts
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=85084067566&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2020.110178
DO - 10.1016/j.biopha.2020.110178
M3 - Article
C2 - 32371317
AN - SCOPUS:85084067566
SN - 0753-3322
VL - 127
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 110178
ER -
