TY - JOUR
T1 - Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology
AU - Trejo-Soto, Claudia
AU - Lázaro, Guillermo R.
AU - Pagonabarraga, Ignacio
AU - Hernández-Machado, Aurora
N1 - Funding Information:
This research was funded by VRIEA/PUCV (Grant No. DIII039.425/2021); ANID/PCI (Grant No. MEC80180021); Ministerio de Ciencia e Innovaci?n (Grant No. PID2019-106063GB-100); MINECO (Grant No. PGC2018-098373-B-100); DURSI (Grant No. 2017 SGR 884), and SNF Project no. 200021-175719.
Funding Information:
Funding: This research was funded by VRIEA/PUCV (Grant No. DIII039.425/2021); ANID/PCI (Grant No. MEC80180021); Ministerio de Ciencia e Innovación (Grant No. PID2019-106063GB-100); MINECO (Grant No. PGC2018-098373-B-100); DURSI (Grant No. 2017 SGR 884), and SNF Project no. 200021-175719.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2
Y1 - 2022/2
N2 - In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes’ characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.
AB - In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes’ characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.
KW - Hemodynamics
KW - Hemorheology
KW - Membrane elasticity
KW - Microfluidics
KW - Red blood cells
UR - http://www.scopus.com/inward/record.url?scp=85124796635&partnerID=8YFLogxK
U2 - 10.3390/membranes12020217
DO - 10.3390/membranes12020217
M3 - Article
AN - SCOPUS:85124796635
VL - 12
JO - Membranes
JF - Membranes
SN - 2077-0375
IS - 2
M1 - 217
ER -