Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology

Claudia Trejo-Soto, Guillermo R. Lázaro, Ignacio Pagonabarraga, Aurora Hernández-Machado

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes’ characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.

Original languageEnglish
Article number217
JournalMembranes
Volume12
Issue number2
DOIs
StatePublished - Feb 2022
Externally publishedYes

Keywords

  • Hemodynamics
  • Hemorheology
  • Membrane elasticity
  • Microfluidics
  • Red blood cells

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