TY - JOUR
T1 - Microrheometer for biofluidic analysis
T2 - Electronic detection of the fluid‐front advancement
AU - Méndez‐mora, Lourdes
AU - Cabello‐fusarés, Maria
AU - Ferré‐torres, Josep
AU - Riera‐llobet, Carla
AU - Lopez, Samantha
AU - TREJO SOTO, CLAUDIA ANDREA
AU - Alarcón, Tomas
AU - Hernandez‐machado, Aurora
N1 - Funding Information:
This research was funded by Generalitat de Catalunya, under grants number 2018 DI 068 and 2018 DI 064; Ministry of Economy and Competitivity (MINECO) under grants number MTM2015?71509?C2?1?R, MDM?2014?0445 and FIS2016?78883?C2?1P; Ministerio de Ciencia e In-novaci?n (Spain) under grant number PID2019?106063GB?100; AGAUR (Generalitat de Catalunya) under project 2017 SGR?1061; ANID/PCI CONICYT (Chile) under project MEC80180021.
Funding Information:
Acknowledgments: Lourdes Méndez‐Mora and Josep Ferré‐Torres acknowledge support from Generalitat de Catalunya under the program Doctorat Industrial (2018 DI 068) and (2018 DI 064). T.A. acknowledges the Spanish MINECO for funding under grant MTM2015‐71509‐C2‐1‐R. Tomas Alarcón acknowledges further support from the Ministry of Economy and Competitivity (MINECO) for funding awarded to the Barcelona Graduate School of Mathematics under the “Maria de Maeztu” program; grant number MDM‐2014‐0445. Tomas Alarcón has been partially funded by the CERCA Programme of the Generalitat de Catalunya. Aurora Hernandez‐Machado acknowledges support from MINECO (Spain) under project FIS2016‐78883‐C2‐1P, Ministerio de Ciencia e Innovación (Spain) under project PID2019‐106063GB‐100, and AGAUR (Generalitat de Catalunya) under project 2017 SGR‐1061. Claudia Trejo‐Soto and Aurora Hernandez‐Machado acknowledge partial support from ANID/PCI CONICYT (Chile) under project MEC80180021. Along the same lines, the authors extend their gratitude toward Rheo Diagnostics S. L. for making this research possible
Funding Information:
Funding: This research was funded by Generalitat de Catalunya, under grants number 2018 DI 068 and 2018 DI 064; Ministry of Economy and Competitivity (MINECO) under grants number MTM2015‐71509‐C2‐1‐R, MDM‐2014‐0445 and FIS2016‐78883‐C2‐1P; Ministerio de Ciencia e In‐ novación (Spain) under grant number PID2019‐106063GB‐100; AGAUR (Generalitat de Catalunya) under project 2017 SGR‐1061; ANID/PCI CONICYT (Chile) under project MEC80180021.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6
Y1 - 2021/6
N2 - The motivation for this study was to develop a microdevice for the precise rheological characterization of biofluids, especially blood. The method presented was based on the principles of rheometry and fluid mechanics at the microscale. Traditional rheometers require a considerable amount of space, are expensive, and require a large volume of sample. A mathematical model was developed that, combined with a proper experimental model, allowed us to characterize the viscosity of Newtonian and non‐Newtonian fluids at different shear rates. The technology presented here is the basis of a point‐of‐care device capable of describing the nonlinear rheology of biofluids by the fluid/air interface front velocity characterization through a microchannel. The proposed microrheometer uses a small amount of sample to deliver fast and accurate results, without need-ing a large laboratory space. Blood samples from healthy donors at distinct hematocrit percentages were the non‐Newtonian fluid selected for the study. Water and plasma were employed as testing Newtonian fluids for validation of the system. The viscosity results obtained for the Newtonian and non‐Newtonian fluids were consistent with pertinent studies cited in this paper. In addition, the results achieved using the proposed method allowed distinguishing between blood samples with different characteristics.
AB - The motivation for this study was to develop a microdevice for the precise rheological characterization of biofluids, especially blood. The method presented was based on the principles of rheometry and fluid mechanics at the microscale. Traditional rheometers require a considerable amount of space, are expensive, and require a large volume of sample. A mathematical model was developed that, combined with a proper experimental model, allowed us to characterize the viscosity of Newtonian and non‐Newtonian fluids at different shear rates. The technology presented here is the basis of a point‐of‐care device capable of describing the nonlinear rheology of biofluids by the fluid/air interface front velocity characterization through a microchannel. The proposed microrheometer uses a small amount of sample to deliver fast and accurate results, without need-ing a large laboratory space. Blood samples from healthy donors at distinct hematocrit percentages were the non‐Newtonian fluid selected for the study. Water and plasma were employed as testing Newtonian fluids for validation of the system. The viscosity results obtained for the Newtonian and non‐Newtonian fluids were consistent with pertinent studies cited in this paper. In addition, the results achieved using the proposed method allowed distinguishing between blood samples with different characteristics.
KW - Blood
KW - Hemorheology
KW - Microrheometer
KW - Plasma
KW - Rheology
KW - Rheometer
KW - Viscosity
UR - http://www.scopus.com/inward/record.url?scp=85109081473&partnerID=8YFLogxK
U2 - 10.3390/mi12060726
DO - 10.3390/mi12060726
M3 - Article
AN - SCOPUS:85109081473
VL - 12
JO - Micromachines
JF - Micromachines
SN - 2072-666X
IS - 6
M1 - 726
ER -