Mineralocorticoids modulate the expression of the β-3 subunit of the Na+, K+-ATPase in the renal collecting duct

Macarena Rojas, Pablo Díaz, Pablo León, ALEXIS ANTONIO GONZALEZ PARRA, Magdalena González, Víctor Barrientos, Nikolay B. Pestov, Rodrigo Alzamora, Luis Michea

Research output: Contribution to journalArticlepeer-review

Abstract

Renal sodium reabsorption depends on the activity of the Na+,K+-ATPase α/β heterodimer. Four α (α1–4) and 3 β (β1–3) subunit isoforms have been described. It is accepted that renal tubule cells express α11 dimers. Aldosterone stimulates Na+,K+-ATPase activity and may modulate α11 expression. However, some studies suggest the presence of β3 in the kidney. We hypothesized that the β3 isoform of the Na+,K+-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that β3 is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of β3. Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.

Original languageEnglish
Pages (from-to)388-398
Number of pages11
JournalChannels
Volume11
Issue number5
DOIs
StatePublished - 3 Sep 2017

Keywords

  • aldosterone
  • epithelial sodium channel
  • hypertension
  • intercalated cells
  • pendrin
  • principal cells
  • sodium pump

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