@article{21b5bba8d82e478a80c3277452029385,
title = "Mineralocorticoids modulate the expression of the β-3 subunit of the Na+, K+-ATPase in the renal collecting duct",
abstract = "Renal sodium reabsorption depends on the activity of the Na+,K+-ATPase α/β heterodimer. Four α (α1–4) and 3 β (β1–3) subunit isoforms have been described. It is accepted that renal tubule cells express α1/β1 dimers. Aldosterone stimulates Na+,K+-ATPase activity and may modulate α1/β1 expression. However, some studies suggest the presence of β3 in the kidney. We hypothesized that the β3 isoform of the Na+,K+-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that β3 is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of β3. Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.",
keywords = "aldosterone, epithelial sodium channel, hypertension, intercalated cells, pendrin, principal cells, sodium pump",
author = "Macarena Rojas and Pablo D{\'i}az and Pablo Le{\'o}n and Gonzalez, {Alexis A.} and Magdalena Gonz{\'a}lez and V{\'i}ctor Barrientos and Pestov, {Nikolay B.} and Rodrigo Alzamora and Luis Michea",
note = "Funding Information: We thank Eliana Pino for general technical assistance. This work was supported by FONDECYT-Regular grants 1130550 (L.M.) and 1151423 (R.A.), FONDECYT-Iniciaci?n 11121217 (A.A.G.), CONICYT-Doctorado 21120658 (P.D.), the Millennium Institute on Immunology and Immunotherapy (MIII) P09/016-F (ICM) and the Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD NC160011). Funding Information: This work was supported by FONDECYT-Regular grants 1130550 (L.M.) and 1151423 (R.A.), FONDECYT-Iniciaci{\'o}n 11121217 (A.A.G.), CONICYT-Doctorado 21120658 (P.D.), the Millennium Institute on Immunology and Immunotherapy (MIII) P09/016-F (ICM) and the Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD NC160011). Publisher Copyright: {\textcopyright} 2017 Taylor & Francis.",
year = "2017",
month = sep,
day = "3",
doi = "10.1080/19336950.2017.1344800",
language = "English",
volume = "11",
pages = "388--398",
journal = "Channels",
issn = "1933-6950",
number = "5",
}