Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials

Keshav Goel, Matias Zuñiga-Bustos, Caitlin Lazurko, Erik Jacques, Constanza Galaz-Araya, FRANCISCO JAVIER VALENZUELA HENRIQUEZ, Natalia L. Pacioni, Jean François Couture, Horacio Poblete, Emilio I. Alarcon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.

Original languageEnglish
Pages (from-to)17697-17705
Number of pages9
JournalACS Applied Materials and Interfaces
Volume11
Issue number19
DOIs
StatePublished - 15 May 2019
Externally publishedYes

Keywords

  • association models
  • cystein-containing peptides
  • isothermal titration calorimetry
  • molecular dynamics
  • nanosurface engineering
  • polydispersity
  • silver nanoparticles

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