Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials

Keshav Goel; Matias Zuñiga-Bustos; Caitlin Lazurko; Erik Jacques; Constanza Galaz-Araya; Francisco Valenzuela-Henriquez; Natalia L. Pacioni; Jean François Couture; Horacio Poblete; Emilio I. Alarcon

doi:10.1021/acsami.9b03942

Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials

Keshav Goel, Matias Zuñiga-Bustos, Caitlin Lazurko, Erik Jacques, Constanza Galaz-Araya, Francisco Valenzuela-Henriquez, Natalia L. Pacioni, Jean François Couture, Horacio Poblete, Emilio I. Alarcon

INSTITUTE OF MATHEMATICS

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8 Scopus citations

Abstract

The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.

Original language	English
Pages (from-to)	17697-17705
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	19
DOIs	https://doi.org/10.1021/acsami.9b03942
State	Published - 15 May 2019

Keywords

association models
cystein-containing peptides
isothermal titration calorimetry
molecular dynamics
nanosurface engineering
polydispersity
silver nanoparticles

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10.1021/acsami.9b03942

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Goel, K., Zuñiga-Bustos, M., Lazurko, C., Jacques, E., Galaz-Araya, C., Valenzuela-Henriquez, F., Pacioni, N. L., Couture, J. F., Poblete, H., & Alarcon, E. I. (2019). Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials. ACS Applied Materials and Interfaces, 11(19), 17697-17705. https://doi.org/10.1021/acsami.9b03942

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title = "Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials",

abstract = "The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.",

keywords = "association models, cystein-containing peptides, isothermal titration calorimetry, molecular dynamics, nanosurface engineering, polydispersity, silver nanoparticles",

author = "Keshav Goel and Matias Zu{\~n}iga-Bustos and Caitlin Lazurko and Erik Jacques and Constanza Galaz-Araya and Francisco Valenzuela-Henriquez and Pacioni, {Natalia L.} and Couture, {Jean Fran{\c c}ois} and Horacio Poblete and Alarcon, {Emilio I.}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = may,

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doi = "10.1021/acsami.9b03942",

language = "English",

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Goel, K, Zuñiga-Bustos, M, Lazurko, C, Jacques, E, Galaz-Araya, C, Valenzuela-Henriquez, F, Pacioni, NL, Couture, JF, Poblete, H & Alarcon, EI 2019, 'Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials', ACS Applied Materials and Interfaces, vol. 11, no. 19, pp. 17697-17705. https://doi.org/10.1021/acsami.9b03942

Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials. / Goel, Keshav; Zuñiga-Bustos, Matias; Lazurko, Caitlin et al.
In: ACS Applied Materials and Interfaces, Vol. 11, No. 19, 15.05.2019, p. 17697-17705.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules

T2 - Toward a Rational Nanoarchitectural Design of Hybrid Materials

AU - Goel, Keshav

AU - Zuñiga-Bustos, Matias

AU - Lazurko, Caitlin

AU - Jacques, Erik

AU - Galaz-Araya, Constanza

AU - Valenzuela-Henriquez, Francisco

AU - Pacioni, Natalia L.

AU - Couture, Jean François

AU - Poblete, Horacio

AU - Alarcon, Emilio I.

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AB - The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.

KW - association models

KW - cystein-containing peptides

KW - isothermal titration calorimetry

KW - molecular dynamics

KW - nanosurface engineering

KW - polydispersity

KW - silver nanoparticles

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JF - ACS Applied Materials and Interfaces

IS - 19

ER -

Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials

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Keywords

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