TY - JOUR
T1 - Navicular Syndrome-related changes to collagen proportion of different cross-sections of the flexor tendons in equine distal forelimb
AU - SALINAS PEREZ, PAULO CRISTIÁN
AU - Lira-Velásquez, Diego
AU - Bongiorno, Anthony
AU - Sandoval, Carlos
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - The aim of this study was to quantify the distribution of aligned and non-aligned collagen in cross-sections of the superficial digital flexor tendon (SDFT) and deep digital flexor tendon (DDFT) in different levels of the distal forelimb of equines diagnosed with NS (Navicular Syndrome). Sixty equine forelimbs were collected. Was compared two groups (NA, Not affected vs. NS-group) by t-Student. Diagnosis of NS was based on clinical and lameness examination, diagnostic analgesia and radiological findings. The proportion of aligned and non-aligned collagens at 2 levels for the SDFT and 3 levels for the DDFT were measured by histochemical stains. The amount of aligned and non-aligned collagen in tendons were calculated using Colour-Based Segmentation function. Regarding collagen, there were significant differences in the amount of aligned collagen (NA: 21.2 ± 1.31; NS-group: 12.2 ± 4.67; p = 0.0026) and non-aligned collagen (NA: 21.8 ± 2.22; NS: 25.1 ± 1.73; p = 0.0241) at the DDFT insertion in the distal phalanx. We concluded that the flexor tendons of the forelimb in equines with NS have different proportions of collagen than those that do not present the diagnosis, indicated by histologically visible increased proportions of non-aligned collagen and decreased of aligned collagen in the extracellular matrix.
AB - The aim of this study was to quantify the distribution of aligned and non-aligned collagen in cross-sections of the superficial digital flexor tendon (SDFT) and deep digital flexor tendon (DDFT) in different levels of the distal forelimb of equines diagnosed with NS (Navicular Syndrome). Sixty equine forelimbs were collected. Was compared two groups (NA, Not affected vs. NS-group) by t-Student. Diagnosis of NS was based on clinical and lameness examination, diagnostic analgesia and radiological findings. The proportion of aligned and non-aligned collagens at 2 levels for the SDFT and 3 levels for the DDFT were measured by histochemical stains. The amount of aligned and non-aligned collagen in tendons were calculated using Colour-Based Segmentation function. Regarding collagen, there were significant differences in the amount of aligned collagen (NA: 21.2 ± 1.31; NS-group: 12.2 ± 4.67; p = 0.0026) and non-aligned collagen (NA: 21.8 ± 2.22; NS: 25.1 ± 1.73; p = 0.0241) at the DDFT insertion in the distal phalanx. We concluded that the flexor tendons of the forelimb in equines with NS have different proportions of collagen than those that do not present the diagnosis, indicated by histologically visible increased proportions of non-aligned collagen and decreased of aligned collagen in the extracellular matrix.
KW - Collagen
KW - Equine
KW - Forelimb
KW - Navicular Syndrome
KW - Tendon
UR - http://www.scopus.com/inward/record.url?scp=85099392168&partnerID=8YFLogxK
U2 - 10.1016/j.rvsc.2021.01.002
DO - 10.1016/j.rvsc.2021.01.002
M3 - Article
AN - SCOPUS:85099392168
VL - 135
SP - 106
EP - 112
JO - Research in Veterinary Science
JF - Research in Veterinary Science
SN - 0034-5288
ER -