F. W. Domke described three Senecio species (Compositae, Senecioneae) from Ecuador on the basis of Diels’s collections. Since the type material at B was apparently destroyed in 1943, the names Senecio angelensis, S. dielsii and S. tipocochensis are neotypified. The nomenclature of each taxonomic entity is updated, and new synonyms are provided for the first time. A lectotype for the name S. sotarensis is also designated. Taxonomic notes are provided when appropriate.