New organometallic Schiff-base copper complexes as efficient "click" reaction precatalysts

Xiang Liu, Néstor Novoa, Carolina Manzur, David Carrillo, Jean René Hamon

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A new ferrocenyl-containing unsymmetrical CuII-Schiff-base complex, 2, and its covalently poly(methyl) (methacrylate) (PMMA)-grafted counterpart 3 were synthesized and characterized using elemental analysis, electrospray ionisation (ESI) mass spectrometry for 2, and FT-IR spectroscopy. New complex 3 was employed as a precatalyst in the copper-catalyzed [3+2] cycloaddition of organic azides to alkynes (CuAAC, "click" reaction). The active CuI species generated from only 0.2 mol% of CuII precatalyst 2 and sodium ascorbate displayed high activity at room temperature in ethanol for 24 hours allowing the synthesis of a wide variety of 1,4-disubstituted 1,2,3-triazoles in high isolated yields. The PMMA-supported catalyst 3 is also efficient and has been reused at least three times in these "click" reactions without any loss of activity or copper leaching.

Original languageEnglish
Pages (from-to)3308-3313
Number of pages6
JournalNew Journal of Chemistry
Issue number4
StatePublished - 1 Apr 2016


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