Background: A higher educational level is associated with healthier lifestyles. Aim: To assess the association between the level of compliance with physical activity recommendations and years of formal education in Chilean adults. Material and Methods: Analysis include 6,174 participants from the National Health Survey 2016-2017. Physical activity levels were assessed through the Global Physical Questionnaire (GPAQ v2). Physical inactivity was defined as < 600 MET/minute/week. Results: Among subjects without education, 44% and 27% of women and men respectively, were physically inactive. Among women and men with the highest number of years of education (> 16) the figures for physical inactivity were 27% and 15% respectively. The odds for not meeting the physical activity recommendations was 2.3 [95% confidence intervals (CI): 1.57; 3.38] and 3.9 [95% CI: 2.27; 6.95] in women and men without any formal education respectively, as compared with those who reported 12 years of education. Women and men who reported a high level of education ≥ (16 years) did not show significant differences compared to the reference group. Conclusions: People with low levels of education are were likely to be physically inactive.