Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

Claudia Trejo-Soto, Aurora Hernández-Machado

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior.

Original languageEnglish
Article number357
JournalMicromachines
Volume13
Issue number3
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • Blood
  • Hematocrit
  • Microfluidics
  • Shear rate
  • Viscosity

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