El estrés prenatal causado por restricción de movimiento induce cambios en la anatomía ósea de cráneo en la progenie de ratones CF-1

Translated title of the contribution: Prenatal stress caused by movement restriction induces changes in the development of skull bone in CF-1 mice progeny

Ricardo Henríquez, Rossy Olivares, Gabriel Caro, Víctor Guevara, PABLO JOSE LIZANA ARCE

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Prenatal stress is associated with changes in body weight and size, and with disorders of the skeletal bone development process. However, there is a lack of documentation on the impact of prenatal stress on skull bone anatomy during the gestation period. Therefore, this research focuses on the short-term effects of prenatal stress on the skull bone anatomy of CF-1 mice on the day of birth. Methodology: Gestating females were divided at random into two groups (control and stressed). The experimental group was subjected to the stress of movement restriction during the final week of gestation. Upon birth the body weight of the progeny was evaluated (control group, n=34; stressed group, n=29). They were then cleaned and stained with alizarin red in order to evaluate the length, width and suture spaces of the skull bone anatomy from superior and inferior views. Results: Gestational stress significantly altered the skull bone anatomy (p<0.05) of the offspring at birth in comparison with the control group. Conclusion: Prenatal stress alters the skull bone anatomy of the CF-1 mouse at birth.

Translated title of the contributionPrenatal stress caused by movement restriction induces changes in the development of skull bone in CF-1 mice progeny
Original languageSpanish
Pages (from-to)1034-1040
Number of pages7
JournalInternational Journal of Morphology
Volume31
Issue number3
DOIs
StatePublished - 3 Dec 2013

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