TY - JOUR
T1 - Propiedad vasodilatadora de solanum crispum Ruiz & Pav. Una planta nativa de américa de sur
AU - Vinet, Raúl
AU - Álvarez, Rocío
AU - Knox, Marcela
AU - Guzmán, Leda
AU - Martínez, José L.
AU - Flores, Eva
N1 - Publisher Copyright:
© 2016.
PY - 2016/3
Y1 - 2016/3
N2 - Solatium crispum Ruiz & Pav. (S. crispum) is a southern South American native plant that is usually used in traditional medicine for the treatment of symptoms associated with both, acute and chronic ailments. Enema and infusion of leaves and stems are used to treat fever, headache, inflammation and hypertension. In this study, we aim to assess the vasoactive effect of hydroalcoholic extracts of S. crispum on isolated rat aorta rings. The hydroalcoholic extract of S. crispum induced a vasodilatory effect (42.6 ± 4.1%) in aortic rings precontracted with phenylephrine (0.1 μM). The aortic relaxation was largely endothelium-dependent and mediated by nitric oxide (NO). The endothelium- and NO-dependence was demonstrated by a drastic fall in the dilatation induced by the extract when the endothelium was removed (10.6 ± 2.3%) and when nitric oxide synthase (NOS) was inhibited (12.3 ± 2.5%) by nitro-L-arginine (L-NNA). This result supports the popular use of S. crispum in the treatment of hypertension that may be due, at least in part, to the vasodilator effect of one o more compounds present in their leaves and stems. Further studies should be performed to clarify this phenomenon.
AB - Solatium crispum Ruiz & Pav. (S. crispum) is a southern South American native plant that is usually used in traditional medicine for the treatment of symptoms associated with both, acute and chronic ailments. Enema and infusion of leaves and stems are used to treat fever, headache, inflammation and hypertension. In this study, we aim to assess the vasoactive effect of hydroalcoholic extracts of S. crispum on isolated rat aorta rings. The hydroalcoholic extract of S. crispum induced a vasodilatory effect (42.6 ± 4.1%) in aortic rings precontracted with phenylephrine (0.1 μM). The aortic relaxation was largely endothelium-dependent and mediated by nitric oxide (NO). The endothelium- and NO-dependence was demonstrated by a drastic fall in the dilatation induced by the extract when the endothelium was removed (10.6 ± 2.3%) and when nitric oxide synthase (NOS) was inhibited (12.3 ± 2.5%) by nitro-L-arginine (L-NNA). This result supports the popular use of S. crispum in the treatment of hypertension that may be due, at least in part, to the vasodilator effect of one o more compounds present in their leaves and stems. Further studies should be performed to clarify this phenomenon.
KW - Rat aorta
KW - Solatium berteroatium
KW - Solatium crispum
KW - Solatium ligustritium
KW - Solatium tomatillo
KW - Witheritigia berteroatia
UR - http://www.scopus.com/inward/record.url?scp=84958582278&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84958582278
VL - 15
SP - 94
EP - 98
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
SN - 0717-7917
IS - 2
ER -