Antígeno prostático específico y NF-kB en patología prostática: Relación con la malignidad

Translated title of the contribution: Prostate specific antigen and NF-kB in prostatic disease: Relation with malignancy

J. R. Cansino, ROSA DE LAS MERCEDES VERA ARAVENA, F. Rodríguez De Bethencourt, Y. Bouraoui, G. Rodríguez, A. Prieto, J. De La Peña, R. Paniagua, M. Royuela

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: NF-kB (p50/p65) is a transcription factor involved in TNF-α-induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB (p50 and p65) with serum levels of prostate-specific antigen (PSA), both in normal males and in those with pathologic conditions of the prostate. Materials and methods: this study was carried out in 5 normal, 24 benign prostatic hyperplastic (BPH) and 19 patients with prostate cancer (PC). Immunohistochemical and Western blot analyses were performed on tissue and serum PSA was assayed by PSA DPC Immulite assays (Diagnostics Products Corporation, Los Angeles, CA). Results: in controls, p65 NF-kB was not found and p50 was scantly detected in 60% normal samples in the cytoplasm of epithelial cells. Both p50 and p65 were expressed in 62.5% of the samples with BPH and in 63.2% of those with PC. Both increased its frequency of expression with higher PSA serum levels. Conclusions: Activation of NF-kB revealed by its nuclear translocation in prostate cancer could be related to cancer progression and elevated seric PSA levels. A better understanding of the biologic mechanism by which circulating PSA levels increase and its relation with NF-kB expression is needed. Possibly, NF-kB blockage could be used as a therapeutic target to counteract proliferation in prostate cancer.

Translated title of the contributionProstate specific antigen and NF-kB in prostatic disease: Relation with malignancy
Original languageSpanish
Pages (from-to)16-21
Number of pages6
JournalActas Urologicas Espanolas
Volume35
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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