This article invites reflection on the design of teaching-learning sequences (TLS) with augmented reality (AR). TLS to understand as the planning document teaching situations and corresponding learning a subject or discipline specific content and Augmented Reality (AR), as the combination of real environments, which information is incorporated digitally extending it our senses show us reality. TLS design with RA for teaching chemistry is the development of the visualization and use of information from 2D contexts (eg textbooks) to one of 3D (ie manipulation, interaction, perspective, complexity, integration etc.) and building bridges between theory and practical experience. In this article we review some examples and prototypes in which we are working from reference literature.