Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi

M. Verónica Rojas, Norbel Galanti

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalFEBS Letters
Issue number1-3
StatePublished - 16 Dec 1991
Externally publishedYes


  • 5-Azacytidine
  • Cell proliferation
  • DNA methylation
  • Trypanosoma cruzi


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