Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi

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Abstract

5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalFEBS Letters
Volume295
Issue number1-3
DOIs
StatePublished - 16 Dec 1991

Keywords

  • 5-Azacytidine
  • Cell proliferation
  • DNA methylation
  • Trypanosoma cruzi

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