Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi

M. Verónica Rojas; Norbel Galanti

doi:10.1016/0014-5793(91)81377-K

Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi

M. Verónica Rojas, Norbel Galanti

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [³H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.

Original language	English
Pages (from-to)	31-34
Number of pages	4
Journal	FEBS Letters
Volume	295
Issue number	1-3
DOIs	https://doi.org/10.1016/0014-5793(91)81377-K
State	Published - 16 Dec 1991
Externally published	Yes

Keywords

5-Azacytidine
Cell proliferation
DNA methylation
Trypanosoma cruzi

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10.1016/0014-5793(91)81377-K

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title = "Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi",

abstract = "5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.",

keywords = "5-Azacytidine, Cell proliferation, DNA methylation, Trypanosoma cruzi",

author = "Rojas, {M. Ver{\'o}nica} and Norbel Galanti",

year = "1991",

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language = "English",

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AU - Rojas, M. Verónica

AU - Galanti, Norbel

PY - 1991/12/16

Y1 - 1991/12/16

N2 - 5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.

AB - 5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.

KW - 5-Azacytidine

KW - Cell proliferation

KW - DNA methylation

KW - Trypanosoma cruzi

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U2 - 10.1016/0014-5793(91)81377-K

DO - 10.1016/0014-5793(91)81377-K

M3 - Article

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AN - SCOPUS:0026329345

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SP - 31

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JO - FEBS Letters

JF - FEBS Letters

IS - 1-3

ER -

Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi

Abstract

Keywords

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