Semisynthetic peptide–lipase conjugates for improved biotransformations

Oscar Romero, Marco Filice, Blanca de las Rivas, Cesar Carrasco-Lopez, Javier Klett, Antonio Morreale, Juan A. Hermoso, Jose M. Guisan, Olga Abian, Jose M. Palomo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

Original languageEnglish
Pages (from-to)9053-9055
Number of pages3
JournalChemical Communications
Volume48
Issue number72
DOIs
StatePublished - 13 Aug 2012
Externally publishedYes

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