TY - JOUR
T1 - Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone
AU - Mellado, Marco
AU - Roldán, Nicole
AU - Miranda, Rodrigo
AU - Aguilar, Luis F.
AU - Bravo, Manuel A.
AU - Quiroz, Waldo
N1 - Funding Information:
This work was supported by the Agencia Nacional de Investigación y Desarrollo (ANID) [Fondecyt Postdoctoral grant 3180408; Fondecyt grant 1191041; Convocatoria Nacional Subvención a Instalación en la Academia Convocatoria año 2021 Folio SA77210078]; and VRIEA-PUCV [37.0/2017].
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (2E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (8) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (Ka) and fluorescence quenching constant (KSV) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be Ka= 9.08 × 104 and KSV= 1.60 × 105, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (8) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer.
AB - Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (2E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (8) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (Ka) and fluorescence quenching constant (KSV) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be Ka= 9.08 × 104 and KSV= 1.60 × 105, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (8) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer.
KW - Chalcone
KW - chemosensor
KW - Mercury(II)
KW - Selective fluorescence quenching
UR - http://www.scopus.com/inward/record.url?scp=85128449912&partnerID=8YFLogxK
U2 - 10.1007/s10895-022-02941-2
DO - 10.1007/s10895-022-02941-2
M3 - Article
AN - SCOPUS:85128449912
JO - Journal of Fluorescence
JF - Journal of Fluorescence
SN - 1053-0509
ER -