Stochastic local search algorithms for the direct aperture optimisation problem in IMRT

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Abstract

In this paper, two heuristic algorithms are proposed to solve the direct aperture optimisation problem (DAO) in radiation therapy for cancer treatment. In the DAO problem, the goal is to find a set of deliverable aperture shapes and intensities so we can irradiate the tumor according to a medical prescription without producing any harm to the surrounding healthy tissues. Unlike the traditional two-step approach used in intensity modulated radiation therapy (IMRT) where the intensities are computed and then the apertures shapes are determined by solving a sequencing problem, in the DAO problem, constraints associated to the number of deliverable aperture shapes as well as physical constraints are taken into account during the intensities optimisation process. Thus, we do not longer need any leaves sequencing procedure after solving the DAO problem. We try our heuristic algorithms on a prostate case and compare the obtained treatment plan to the one obtained using the traditional two-step approach. Results show that our algorithms are able to find treatment plans that are very competitive when considering the number of deliverable aperture shapes.

Original languageEnglish
Title of host publicationHybrid Metaheuristics - 11th International Workshop, HM 2019, Proceedings
EditorsMaria J. Blesa Aguilera, Christian Blum, Pedro Pinacho-Davidson, Julio Godoy del Campo, Haroldo Gambini Santos
PublisherSpringer Verlag
Pages108-123
Number of pages16
ISBN (Print)9783030059828
DOIs
StatePublished - 1 Jan 2019
Event11th International Workshop on Hybrid Metaheuristics, HM 2019 - Concepción, Chile
Duration: 16 Jan 201918 Jan 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11299 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Workshop on Hybrid Metaheuristics, HM 2019
Country/TerritoryChile
CityConcepción
Period16/01/1918/01/19

Keywords

  • Direct aperture optimisation
  • Intensity modulated radiation therapy
  • Multi-leaf collimator sequencing

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