Study of the hemodynamics effects of an isolated systolic hypertension (Ish) condition on cerebral aneurysms models, using fsi simulations

José Barahona, Alvaro Valencia, María Torres

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hemodynamics is recognized as a relevant factor in the development and rupture of cerebral aneurysms, so further studies related to different physiological conditions in human represent an advance in understanding the pathology and rupture risk. In this paper, Fluid-structure interaction simulations (FSI) were carried out in six models of cerebral aneurysms, in order to study the hemo-dynamics effects of an isolated systolic hypertension (ISH) condition and compare it to a normal or normotensive pressure condition and a higher hypertension condition. Interestingly, the ISH condition showed, in general, the greatest hemodynamics changes, evidenced in the Time-Averaged Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI), and Relative Residence Time (RRT) parameters, with respect to a normal condition. These results could imply that a not high-pressure condition (ISH), characterized with a different shape and an abrupt change in its diastolic and systolic range may present more adverse hemodynamic changes compared to a higher-pressure condition (such as a hypertensive condition) and therefore have a greater incidence on the arterial wall remodeling and rupture risk.

Original languageEnglish
Article number2595
JournalApplied Sciences (Switzerland)
Volume11
Issue number6
DOIs
StatePublished - 2 Mar 2021

Keywords

  • Cerebral aneurysm
  • FSI
  • Hemodynamics
  • Isolated systolic hypertension
  • Rupture risk

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