Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

Enrique Werner, Iván Montenegro, Bastian Said, Patricio Godoy, XIMENA ALEJANDRA BESOAIN CANALES, Nelson Caro, Alejandro Madrid

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.

Original languageEnglish
Article number317
Pages (from-to)1-8
Number of pages8
JournalAntibiotics
Volume9
Issue number6
DOIs
StatePublished - Jun 2020
Externally publishedYes

Keywords

  • 2’,4’-dihydroxydihydrochalcone
  • Anti-Saprolegnia activity
  • Lipophilicity
  • Oxyalkylated derivatives

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