Synthesis, characterization, and crystal structure of 2′,2″-dihydroxy-3,3⌄-bichalcone and its related chalcone-flavanone and biflavanone analogs

Carlos A. Escobar, Williams A. Fernández, Alexander Trujillo, Juan C. Santos, Thierry Roisnel, Mauricio Fuentealba

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The synthesis of 3,3′-diformyl-1,1′-biphenyl 1 and its reaction in basic media with 2′-hydroxyacetophenone and paeonol, respectively, are described. The products, a bichalcone 2, it's partially cyclized analog, a flavanone-chalcone 3 and the fully cyclized biflavanone 4, are reported as products for the first reaction, while only the chalcone 5 for the second. The crystalline and molecular structure, solved by X-ray diffraction analysis, for compounds 2 and 5 are also presented in this work.

Original languageEnglish
Pages (from-to)5271-5274
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number38
DOIs
StatePublished - 17 Sep 2014
Externally publishedYes

Keywords

  • Bichalcone
  • Biflavanone
  • Biphenyl
  • Chalcone
  • Flavanone-chalcone

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