Synthesis, Crystal Structure, and Photophysical Properties of 4-(4-(Dimethylamino)phenyl)-6-phenylpyrimidin-2-amine

Marco Mellado, Rafaela Sariego-Kluge, Franco Valdés-Navarro, Rodrigo Sánchez-González, Mauricio Fuentealba, Manuel A. Bravo, Luis F. Aguilar

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The pyrimidine core is present in a wide variety of compounds that show interesting fluorescent properties and have been used as pigments and dyes. In this research, we synthesized 4-(4-(dimethylamino)phenyl)-6-phenylpyrimidin-2-amine (compound 9) from chalcone (8) with 45% yield. We obtained monocrystals of 9 by slow evaporation of dichloromethane as a solvent. Additionally, we measured the photophysical properties of compound 9, and its absorption wavelength (λabs), molar absorption coefficient (ε), excitation wavelength (λexc) and emission wavelength (λem), as well as Stokes shift (Δλ), increase with increasing solvent polarity. These properties are all related to the stabilization of the excited state by the solvent.

Original languageEnglish
Article number129340
JournalJournal of Molecular Structure
StatePublished - 15 Feb 2021


  • 2-amino-pyrimidin
  • Absorption properties
  • Chalcone
  • Crystal structure
  • Emission properties


Dive into the research topics of 'Synthesis, Crystal Structure, and Photophysical Properties of 4-(4-(Dimethylamino)phenyl)-6-phenylpyrimidin-2-amine'. Together they form a unique fingerprint.

Cite this