Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity

M. Filice, O. Romero, J. Gutiérrez-Fernández, B. De Las Rivas, J. A. Hermoso, J. M. Palomo

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A solid-phase strategy using lipase as a biomolecular scaffold to produce a large amount of Cu2+-metalloenzyme is proposed here. The application of this protocol on different 3D cavities of the enzyme allows creating a heterogeneous artificial metallolipase showing chimeric catalytic activity. The artificial catalyst was assessed in Diels-Alder cycloaddition reactions and cascade reactions showing excellent catalytic properties.

Original languageEnglish
Pages (from-to)9324-9327
Number of pages4
JournalChemical Communications
Volume51
Issue number45
DOIs
StatePublished - 7 Jun 2015
Externally publishedYes

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