Synthesis of N-acylated 1,5-benzodiazepines: Differentiation between two possible acylation sites via hydrogen bonding

Medicine & Life Sciences

• acetic anhydride 100%
• Acylation 80%
• Hydrogen Bonding 70%
• Benzodiazepines 60%
• Temperature 42%
• Molecular Structure 35%
• X-Ray Diffraction 35%
• Hydroxyl Radical 32%
• Chlorides 31%
• 4-(2-hydroxyphenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine 4%

Chemistry

• Acetic Anhydride 61%
• Acylation 57%
• Hydrogen 29%
• Regioselectivity 27%
• Amino Groups 24%
• Molecular Structure 20%
• Chloride 17%
• Ambient Reaction Temperature 16%
• X-Ray Diffraction 14%